Gene Expression Literature Summary

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Tfap2a  transcription factor AP-2, alpha   (Synonyms: Ap2, Ap-2 (a), AP2alpha, AP-2 alpha, Ap2tf, Tcfap2a)
Results	Reference
1*	J:205268 Ahmad N, Aslam M, Muenster D, Horsch M, Khan MA, Carlsson P, Beckers J, Graw J, Pitx3 directly regulates Foxe3 during early lens development. Int J Dev Biol. 2013;57(9-10):741-51
1*	J:237938 Amin MB, Miura N, Uddin MK, Islam MJ, Yoshida N, Iseki S, Kume T, Trainor PA, Saitsu H, Aoto K, Foxc2CreERT2 knock-in mice mark stage-specific Foxc2-expressing cells during mouse organogenesis. Congenit Anom (Kyoto). 2017 Jan;57(1):24-31
1	J:222437 Aoto K, Sandell LL, Butler Tjaden NE, Yuen KC, Watt KE, Black BL, Durnin M, Trainor PA, Mef2c-F10N enhancer driven beta-galactosidase (LacZ) and Cre recombinase mice facilitate analyses of gene function and lineage fate in neural crest cells. Dev Biol. 2015 Jun 1;402(1):3-16
1*	J:231312 Baardman ME, Zwier MV, Wisse LJ, Gittenberger-de Groot AC, Kerstjens-Frederikse WS, Hofstra RM, Jurdzinski A, Hierck BP, Jongbloed MR, Berger RM, Plosch T, DeRuiter MC, Common arterial trunk and ventricular non-compaction in Lrp2 knockout mice indicate a crucial role of LRP2 in cardiac development. Dis Model Mech. 2016 Apr 1;9(4):413-25
1	J:158712 Bassett EA, Williams T, Zacharias AL, Gage PJ, Fuhrmann S, West-Mays JA, AP-2alpha knockout mice exhibit optic cup patterning defects and failure of optic stalk morphogenesis. Hum Mol Genet. 2010 May 1;19(9):1791-804
1	J:327336 Bertol JW, Johnston S, Ahmed R, Xie VK, Hubka KM, Cruz L, Nitschke L, Stetsiv M, Goering JP, Nistor P, Lowell S, Hoskens H, Claes P, Weinberg SM, Saadi I, Farach-Carson MC, Fakhouri WD, TWIST1 interacts with beta/delta-catenins during neural tube development and regulates fate transition in cranial neural crest cells. Development. 2022 Aug 1;149(15):dev200068
1	J:100584 Byrd NA, Meyers EN, Loss of Gbx2 results in neural crest cell patterning and pharyngeal arch artery defects in the mouse embryo. Dev Biol. 2005 Aug 1;284(1):233-45
1	J:169235 Carbe C, Zhang X, Lens induction requires attenuation of ERK signaling by Nf1. Hum Mol Genet. 2011 Apr 1;20(7):1315-23
1	J:298672 Christ A, Marczenke M, Willnow TE, LRP2 controls sonic hedgehog-dependent differentiation of cardiac progenitor cells during outflow tract formation. Hum Mol Genet. 2020 Nov 25;29(19):3183-3196
1	J:178934 Freyer L, Aggarwal V, Morrow BE, Dual embryonic origin of the mammalian otic vesicle forming the inner ear. Development. 2011 Dec;138(24):5403-14
1	J:252092 Gard C, Gonzalez Curto G, Frarma YE, Chollet E, Duval N, Auzie V, Aurade F, Vigier L, Relaix F, Pierani A, Causeret F, Ribes V, Pax3- and Pax7-mediated Dbx1 regulation orchestrates the patterning of intermediate spinal interneurons. Dev Biol. 2017 Dec 1;432(1):24-33
1	J:135134 Goddeeris MM, Schwartz R, Klingensmith J, Meyers EN, Independent requirements for Hedgehog signaling by both the anterior heart field and neural crest cells for outflow tract development. Development. 2007 Apr;134(8):1593-604
1	J:69286 Haack H, Hynes RO, Integrin receptors are required for cell survival and proliferation during development of the peripheral glial lineage. Dev Biol. 2001 May 1;233(1):38-55
1*	J:139635 Huang X, Goudy SL, Ketova T, Litingtung Y, Chiang C, Gli3-deficient mice exhibit cleft palate associated with abnormal tongue development. Dev Dyn. 2008 Sep 24;237(10):3079-3087
1	J:171842 Jain R, Engleka KA, Rentschler SL, Manderfield LJ, Li L, Yuan L, Epstein JA, Cardiac neural crest orchestrates remodeling and functional maturation of mouse semilunar valves. J Clin Invest. 2011 Jan 4;121(1):422-30
1	J:311535 Khasawneh RR, Kist R, Queen R, Hussain R, Coxhead J, Schneider JE, Mohun TJ, Zaffran S, Peters H, Phillips HM, Bamforth SD, Msx1 haploinsufficiency modifies the Pax9-deficient cardiovascular phenotype. BMC Dev Biol. 2021 Oct 6;21(1):14
1	J:270967 Kodo K, Shibata S, Miyagawa-Tomita S, Ong SG, Takahashi H, Kume T, Okano H, Matsuoka R, Yamagishi H, Regulation of Sema3c and the Interaction between Cardiac Neural Crest and Second Heart Field during Outflow Tract Development. Sci Rep. 2017 Jul 28;7(1):6771
1*	J:63183 Kramer PR, Guerrero G, Krishnamurthy R, Mitchell PJ, Wray S, Ectopic expression of luteinizing hormone-releasing hormone and peripherin in the respiratory epithelium of mice lacking transcription factor AP-2alpha. Mech Dev. 2000 Jun;94(1-2):79-94
1	J:181272 Le TT, Conley KW, Mead TJ, Rowan S, Yutzey KE, Brown NL, Requirements for Jag1-Rbpj mediated Notch signaling during early mouse lens development. Dev Dyn. 2012 Mar;241(3):493-504
1	J:315858 Leung C, Liu Y, Lu X, Kim M, Drysdale TA, Feng Q, Rac1 Signaling Is Required for Anterior Second Heart Field Cellular Organization and Cardiac Outflow Tract Development. J Am Heart Assoc. 2015 Dec 31;5(1)
1	J:293699 Lin JI, Feinstein TN, Jha A, McCleary JT, Xu J, Arrigo AB, Rong G, Maclay LM, Ridge T, Xu X, Lo CW, Mutation of LRP1 in cardiac neural crest cells causes congenital heart defects by perturbing outflow lengthening. Commun Biol. 2020 Jun 16;3(1):312
1	J:229604 Machon O, Masek J, Machonova O, Krauss S, Kozmik Z, Meis2 is essential for cranial and cardiac neural crest development. BMC Dev Biol. 2015;15:40
1	J:160496 Makki N, Capecchi MR, Hoxa1 lineage tracing indicates a direct role for Hoxa1 in the development of the inner ear, the heart, and the third rhombomere. Dev Biol. 2010 May 15;341(2):499-509
1	J:240081 Mayeuf-Louchart A, Montarras D, Bodin C, Kume T, Vincent SD, Buckingham M, Endothelial cell specification in the somite is compromised in Pax3-positive progenitors of Foxc1/2 conditional mutants, with loss of forelimb myogenesis. Development. 2016 Mar 01;143(5):872-9
1*	J:306393 Ofek S, Wiszniak S, Kagan S, Tondl M, Schwarz Q, Kalcheim C, Notch signaling is a critical initiator of roof plate formation as revealed by the use of RNA profiling of the dorsal neural tube. BMC Biol. 2021 Apr 23;19(1):84
1	J:167713 Okubo T, Kawamura A, Takahashi J, Yagi H, Morishima M, Matsuoka R, Takada S, Ripply3, a Tbx1 repressor, is required for development of the pharyngeal apparatus and its derivatives in mice. Development. 2011 Jan;138(2):339-48
1	J:119651 Pan Y, Woodbury A, Esko JD, Grobe K, Zhang X, Heparan sulfate biosynthetic gene Ndst1 is required for FGF signaling in early lens development. Development. 2006 Dec;133(24):4933-44
1*	J:103131 Purcell P, Oliver G, Mardon G, Donner AL, Maas RL, Pax6-dependence of Six3, Eya1 and Dach1 expression during lens and nasal placode induction. Gene Expr Patterns. 2005 Dec;6(1):110-8
1	J:173638 Schmidt M, Huber L, Majdazari A, Schutz G, Williams T, Rohrer H, The transcription factors AP-2beta and AP-2alpha are required for survival of sympathetic progenitors and differentiated sympathetic neurons. Dev Biol. 2011 Jul 1;355(1):89-100
1	J:281204 Sen R, Pezoa SA, Carpio Shull L, Hernandez-Lagunas L, Niswander LA, Artinger KB, Kat2a and Kat2b Acetyltransferase Activity Regulates Craniofacial Cartilage and Bone Differentiation in Zebrafish and Mice. J Dev Biol. 2018 Nov 12;6(4)
1	J:101264 Smith AN, Miller LA, Song N, Taketo MM, Lang RA, The duality of beta-catenin function: a requirement in lens morphogenesis and signaling suppression of lens fate in periocular ectoderm. Dev Biol. 2005 Sep 15;285(2):477-89
1	J:311908 Vogel JK, Weider M, Engler LA, Hillgartner S, Schmitt C, Hermans-Borgmeyer I, Wegner M, Sox9 overexpression exerts multiple stage-dependent effects on mouse spinal cord development. Glia. 2020 May;68(5):932-946
1	J:52402 West-Mays JA, Zhang J, Nottoli T, Hagopian-Donaldson S, Libby D, Strissel KJ, Williams T, AP-2alpha transcription factor is required for early morphogenesis of the lens vesicle. Dev Biol. 1999 Feb 1;206(1):46-62
1	J:196616 Willaredt MA, Gorgas K, Gardner HA, Tucker KL, Multiple essential roles for primary cilia in heart development. Cilia. 2012;1(1):23
1*	J:310864 Zainolabidin N, Kamath SP, Thanawalla AR, Chen AI, Distinct Activities of Tfap2A and Tfap2B in the Specification of GABAergic Interneurons in the Developing Cerebellum. Front Mol Neurosci. 2017;10:281
1	J:243987 Zalc A, Rattenbach R, Aurade F, Cadot B, Relaix F, Pax3 and Pax7 play essential safeguard functions against environmental stress-induced birth defects. Dev Cell. 2015 Apr 06;33(1):56-66
1	J:336422 Zbasnik N, Fish JL, Fgf8 regulates first pharyngeal arch segmentation through pouch-cleft interactions. Front Cell Dev Biol. 2023;11:1186526
1	J:199412 Zhang T, Liu J, Zhang J, Thekkethottiyil EB, Macatee TL, Ismat FA, Wang F, Stoller JZ, Jun is required in Isl1-expressing progenitor cells for cardiovascular development. PLoS One. 2013;8(2):e57032